Videos · Health & Wellbeing
What Is Progesterone Intolerance?
12 June 2026
Progesterone can be incredibly helpful for some women, especially for sleep and anxiety, but not everyone responds that way. For women with progesterone intolerance, it can cause the opposite effect: more anxiety, irritability, bloating, or mood changes. The important thing to know is that this does not automatically mean estrogen is off the table. If you have a uterus, you still need uterine protection when using estrogen, but there are other options to discuss, including different progestins, a progesterone-releasing IUD, or Duavee. If progesterone mak… Video by YouTube channel.